A Matteson Homologation‐Based Synthesis of Doliculide and Derivatives

Doliculide belongs to a group of marine cyclodepsipeptides with interesting biological properties. Apart from halogenated dipeptide, polyketide fragment containing 5 stereogenic centers is the most eye-catching element. This building block can be synthesized in highly stereoselective fashion using only one key reaction: Matteson homologation. straightforward protocol allows for introduction wide range substituents at almost any position growing carbon chain and it therefore perfectly suited synthesis derivatives structure-activity relationship studies